First order kinetics is a concentration-dependent process (i.e. the higher the concentration, the faster the clearance), whereas zero order elimination rate is independent of concentration.Click to see full answer. Regarding this, what is the difference between first order and zero order kinetics?The fundamental difference between zero and first-order kinetics is their elimination rate compared to total plasma concentration. Zero-order kinetics undergo constant elimination regardless of the plasma concentration, following a linear elimination phase as the system becomes saturated.Also Know, what is a zero order drug? Zero order kinetics is a way of describing how the body uses and breaks down some medicines. While the rate at which the body eliminates most drugs is proportional to the concentration administered, known as first order kinetics, drugs that work by zero order kinetics work at a predictable, constant rate. Keeping this in consideration, what is first order elimination? Definition First order elimination kinetics : “Elimination of a constant fraction per time unit of the drug quantity present in the organism. The elimination is proportional to the drug concentration.”What is first order pharmacokinetics?First order kinetics occur when a constant proportion of the drug is eliminated per unit time. Rate of elimination is proportional to the amount of drug in the body. The higher the concentration, the greater the amount of drug eliminated per unit time.
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